MyBioSource.com's ARNT Antibody (Center V528) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, and Western Blot. The ARNT Antibody (Center V528) was generated using ARNT, ARNT1, HIF1 beta, and Hif1b as the antigen and it reacts with Human.
Description
The aryl hydrocarbon (Ah) receptor is involved in the
induction of several enzymes that participate in xenobiotic
metabolism. The ligand-free, cytosolic form of the Ah receptor is
complexed to heat shock protein 90. Binding of ligand, which
includes dioxin and polycyclic aromatic hydrocarbons, results in
translocation of the ligand-binding subunit only to the nucleus.
Induction of enzymes involved in xenobiotic metabolism occurs
through binding of the ligand-bound Ah receptor to xenobiotic
responsive elements in the promoters of genes for these enzymes.
This gene encodes a protein that forms a complex with the
ligand-bound Ah receptor, and is required for receptor function.
The encoded protein has also been identified as the beta subunit of
a heterodimeric transcription factor, hypoxia-inducible factor 1. A
t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion
protein, is associated with acute myeloblastic leukemia.
Alternative splicing results in multiple transcript variants